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Observation

Using an O2 consumption rate of 1 fmol/min/cell, which was not observed in any transformant among 158 derived from individuals 20 weeks (fetal) to 37 years of age, as a cut-off to identify respiratory-deficient clones, 11 such clones were found among 198 transformants derived from individuals 39-103 years of age.

Mapping in APK: for APKID_26224 Age 39 - 103 years is linked via AgeOfObservation to , FETAL,, O2,, | "Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells." J Biol Chem 1996; [PMID: 8663253]


Large-scale screening of the mtDNA main control region in leukocytes from subjects of an Italian population revealed a homoplasmic C150T transition near an origin of heavy mtDNA-strand synthesis in approximately 17% of 52 subjects 99-106 years old, but, in contrast, in only 3.4% of 117 younger individuals (P = 0.0035).

Mapping in APK: for APKID_17788 Age 99 - 106 years is linked via AgeOfObservation to , LEUKOCYTES, TRANSITION,, MTDNA,, | "Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes." Proc Natl Acad Sci U S A 2003; [PMID: 12538859]


Finally, formyl-methionyl-leucyl-phenylanaline (FMLP)-triggered O2- release was reduced in all elderly groups, while depression of O2- production was seen in subjects between the age of 86 and 104 years using phorbol 12-myristate 13-acetate (PMA) as agonist.

Mapping in APK: for APKID_30920 Age 86 - 104 years is linked via AgeOfObservation to , DEPRESSION,, PHORBOL, PMA, AGONIST,, | "Age-associated changes of neutrophil responsiveness in a human healthy elderly population." Cytobios 1994; [PMID: 7774287]



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